GR 82334

Research use only, not for human use.

Tachykinin NK1 receptor antagonist.

Tachykinin NK1 receptor antagonist.

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GR 82334 (intrathecal administration; 0.1 nmol-1 nmol) excites rats unnary bladder motihty at 1 nmol but not at 0.1 nmol, and the reflex chemonociceptive is reduced by the topical application of capsaicin (4 μg/50 ul).GR 82334 (10 nM-1 μM; injected between vertebrae L4 and L5) has no effect at 10 nM in neither species, increases heat-induced foot withdrawal latency in mice at doses >100 nM, but no such increase in naked mole-rats, where doses >100 nM evoke a tendency for decreased latency. Animal Model:3-6 month-old, male C57BL/6 mice and 6-18 month-old naked mole-rats Dosage:10 nM, 100 nM, and 1 μM Administration:Lntrathecal injection between vertebrae L4 and L5?Result:Increased heat-induced foot withdrawal latency in mice.

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Others

Other Targets

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129623-01-4

1386.57

C69H91N15O16

>98% (HPLC)

water:1 mg/mL

CC(C)C[C@H](N1CC[C@@]2(CCCN2C(=O)[C@H](CC2=CC=C(O)C=C2)NC(=O)[C@H](CC2=CC=CC=C2)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]2CCCN2C(=O)[C@H](CC(O)=O)NC(=O)[C@H](C)NC(=O)[C@@H]2CCC(=O)N2)C1=O)C(=O)N[C@@H](CC1=CNC2=C1C=CC=C2)C(N)=O

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(-20℃)

With Ice Pack

≥ 2 years